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- Anti-Mouse PD-1 (CD279) [RMP1-14] In Vivo Antibody - Ultra Low Endotoxin (IVMB0038)
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Product Description
Anti-Mouse PD-1 (CD279) [RMP1-14] In Vivo Antibody - Ultra Low Endotoxin
Introducing the Anti-Mouse PD-1 [CD279, RMP1-14] In Vivo Antibody - Ultra Low Endotoxin from Assay Genie, a highly specific monoclonal antibody designed for in vivo applications. This antibody targets the PD-1 (Programmed Cell Death Protein 1), a critical immune checkpoint receptor playing a pivotal role in regulating immune responses, making it ideal for research in immunology, cancer biology, and related fields. With a rat IgG2a isotype, it ensures high purity and ultra-low endotoxin levels (<0.002 EU/µg), perfect for in vivo studies, flow cytometry, functional assays, and other experimental applications. Available in various sizes, it is formulated in a preservative-free phosphate-buffered saline (PBS) solution, ensuring stability and efficacy.
Enhance your research with this reliable and versatile antibody designed to help uncover the intricacies of immune checkpoint pathways and their implications in disease and therapy. PD-1 is a cell surface receptor expressed on T-cells and pro-B cells that plays a significant role in downregulating the immune system by preventing the activation of T-cells, thus promoting self-tolerance and preventing autoimmune diseases. It achieves this through interactions with its ligands, PD-L1 and PD-L2, which are often upregulated in various tumors to evade immune surveillance.
| Product Name: | Anti-Mouse PD-1 (CD279) [RMP1-14] In Vivo Antibody - Ultra Low Endotoxin |
| Product Code: | IVMB0038 |
| Size: | 1mg, 5mg, 25mg, 50mg, 100mg |
| Clone: | RMP1-14 |
| Protein: | PD-1 |
| Product Type: | Monoclonal Antibody |
| Synonyms: | Programmed Death-1, CD279, PD 1 |
| Isotype: | Rat IgG2a κ |
| Reactivity: | Mouse |
| Immunogen: | Mouse PD-1 transfected BHK cells |
| Applications: | B, FA, WB |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Endotoxin Level: | <0.5 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Applications: | B, FA, WB |
| Reactivity: | Mouse |
| Host Species: | Rat |
| Specificity: | Clone RMP1-14 recognizes an epitope on mouse PD-1. |
| Antigen Distribution: | PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells. |
| Immunogen: | Mouse PD-1 transfected BHK cells |
| Concentration: | ≥7.0 mg/ml |
| Endotoxin Level: | <0.5 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
PD-1 is a 50-55 kD member of the B7 Ig superfamily. PD-1 is also a member of the extended CD28/CTLA-4 family of T cell regulators and is suspected to play a role in lymphocyte clonal selection and peripheral tolerance. The ligands of PD-1 are PD-L1 and PD-L2, and are also members of the B7 Ig superfamily. PD-1 and its ligands negatively regulate immune responses. PD-L1, or B7-Homolog 1, is a 40 kD type I transmembrane protein that has been reported to costimulate T cell growth and cytokine production. The interaction of PD-1 with its ligand PD-L1 is critical in the inhibition of T cell responses that include T cell proliferation and cytokine production. PD-L1 has increased expression in several cancers. Inhibition of the interaction between PD-1 and PD-L1 can serve as an immune checkpoint blockade by improving T-cell responses In vitro and mediating preclinical antitumor activity. Within the field of checkpoint inhibition, combination therapy using anti-PD1 in conjunction with anti-CTLA4 has significant therapeutic potential for tumor treatments. PD-L2 is a 25 kD type I transmembrane ligand of PD-1. Via PD-1, PD-L2 can serve as a co-inhibitor of T cell functions. Regulation of T cell responses, including enhanced T cell proliferation and cytokine production, can result from mAbs that block the PD-L2 and PD-1 interaction.
| Datasheet: | View |
| Protein: | PD-1 |
| Function: | Lymphocyte clonal selection, peripheral tolerance |
| Ligand/Receptor: | PD-L1 (B7-H1), PD-L2 |
| Research Area: | Apoptosis, Cancer, Cell Biology, Cell Death, Immunology, Inhibitory Molecules, Tumor Suppressors |
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| Bikoriman et al. | Local Delivery of Accutox® Synergises With Immune-checkpoint Inhibitors at Disrupting Tumor Growth | Defence Therapeutics 2024 | View Citation |
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