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- Anti-Mouse IL-2 [JES6-1A12] In Vivo Antibody - Low Endotoxin (IVMB0024)
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Product Description
Anti-Mouse IL-2 [JES6-1A12] In Vivo Antibody - Low Endotoxin
Introducing the Anti-Mouse IL-2 [JES6-1A12] In Vivo Antibody - Low Endotoxin from Assay Genie, a highly specific monoclonal antibody designed for in vivo applications. This antibody targets the Interleukin-2 (IL-2) protein, a crucial cytokine in the immune response, making it ideal for research in immunology and related fields.
With a rat IgG2a isotype, it ensures high purity and low endotoxin levels (<1.0 EU/mg), perfect for ELISA, neutralization, flow cytometry, and other assays. Available in various sizes, it is formulated in phosphate-buffered saline for stability and efficacy. Enhance your research with this reliable and versatile antibody. IL-2 is a potent cytokine produced primarily by activated T-cells and is instrumental in the proliferation, differentiation, and survival of antigen-selected cytotoxic T-cells, thereby playing a significant role in the immune system. It also supports the development of regulatory T-cells and promotes the activation and expansion of natural killer cells, enhancing the body's ability to mount an effective immune response.
| Product Name: | Anti-Mouse IL-2 [JES6-1A12] In Vivo Antibody - Low Endotoxin |
| Product Code: | IVMB0024 |
| Size: | 1mg |
| Clone: | JES6-1A12 |
| Protein: | IL-2 |
| Product Type: | Monoclonal Antibody |
| Synonyms: | TCGF, Lymphokine, T-Cell Growth Factor |
| Isotype: | Rat IgG2a κ |
| Reactivity: | Mouse |
| Immunogen: | Purified Recombinant Mouse IL-2 (>98%) |
| Applications: | IP, N, WB |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Applications: | IP, N, WB |
| Reactivity: | Mouse |
| Host Species: | Rat |
| Specificity: | Clone JES6-1A12 recognizes an epitope on mouse IL-2. |
| Immunogen: | Purified Recombinant Mouse IL-2 (>98%) |
| Concentration: | ≥ 5.0 mg/ml |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
IL-2 is a 17.2 kD cytokine signaling protein that is the regulator of the proliferative and suppressive phases of the immune response, and stimulates growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendrocytes. It functions as a primary regulator of T cell homeostasis. Il-2 regulates the activities of white blood cells and plays a role in the immune system via “self” and “non-self” discrimination. IL-2 is a prime candidate in immunotherapeutics for both increasing T cell levels/function and for augmenting vaccine-elicited viral-specific T cell responses. IL-2 signal can be transduced via 3 different signaling pathways that include the JAK-STAT, PI3K/Akt/mTOR and MAPK/ERK pathways. Aldesleukin is a form of recombinant interleukin-2 for the treatment of cancers including malignant melanoma and renal cell cancer. Furthermore, there is additional therapeutic potential for IL-2 mAb use with transplants and autoimmune disease.
| Datasheet: | View |
| Protein: | IL-2 |
| Ligand/Receptor: | High affinity heterotrimer of IL-2Rα/β/γ, intermediate affinity homodimer IL-2Rα (CD25; p55; Tac) and heterodimer IL-2Rβ (CD122)/γ; γ-subunit (CD132) in common with IL-4R, IL-7R, IL-13R, IL-15R |
| Research Area: | Immunology |
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